Drug Scaffolds

Scaffolds are usually rigid, hetero-cycle based structures with functional groups that can be further modified. A large number of marketed drugs contain core scaffolds, for example, Atorvastatin, Sildenafil, and Erlotinib, to name a few. It appears that the major role of the scaffold in a drug molecule is to position those attached functional groups in a right direction and facilitate their proper interaction with biological targets. Therefore, tuning scaffolds is a proven strategy to discover drugs with improved therapeutic index.
At SyncoZymes, we have designed and synthesized over 400 novel and drug-like scaffolds. We can also design and synthesize novel scaffolds tailored to your need. Please feel free to contact us for your drug discovery needs.

 Scaffolds List    1 |2 |3 |4 |5 |6 |7 |8 |9 |10 |11 |12 |13 |14 |15 |16 |17 |18 |19 |20 |21 |22 |23 |24 |25 |    more...

ProductID	Structure	Product Name	Formula and Molecular Weight	CAS Number
SL-001A		2-(2-(tert-butoxycarbonyl)thiazol-5-yl)acetic acid	C10H14N2O4S Mol. Wt.: 258.29	723278-39-5
SL-001B		tert-butyl-5-(2-aminoethyl)thiazol-2-ylcarbamate	C10H17N3O2S Mol. Wt.: 243.33
SL-001C		Ethyl 2-(2-aminothiazol-5-yl)acetate	C7H10N2O2S Mol. Wt.: 186.23	859522-19-3
SL-002A		2-(methylthio)pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one	C6H6N4OS Mol. Wt.: 182.2	54346-18-8
SL-002B		4-chloro-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazine	C6H5ClN4S Mol. Wt.: 200.65	54346-19-9
SL-003A		7-benzyl-4-chloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride	C14H15Cl2N3 Mol. Wt.: 296.19	192869-80-0
sl-003b		ethyl 2-(5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)acetate hydrochloride	C11H16ClN3O2 Mol. Wt.: 257.72	1187830-52-9
SL-003C		5,6,7,8-tetrahydro-4-methoxypyrido[3,4-d]pyrimidine hydrochloride	C8H12ClN3O Mol. Wt.: 201.65	1187830-77-8
SL-003D		5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one hydrochloride	C7H10ClN3O Mol. Wt.: 187.63	1171334-07-8
SL-003E		2-(7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)ethanamine	C8H12ClN3 Mol. Wt.: 185.65
SL-003F		5,6,7,8-tetrahydro-4-methylpyrido[3,4-d]pyrimidine hydrochloride	C8H12ClN3 Mol. Wt.: 185.65	1187830-72-3
SL-004A		6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one	C14H15N3O Mol. Wt.: 241.29	109229-22-3

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Total Records:1140