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Drug Scaffolds

Scaffolds are usually rigid, hetero-cycle based structures with functional groups that can be further modified. A large number of marketed drugs contain core scaffolds, for example, Atorvastatin, Sildenafil, and Erlotinib, to name a few. It appears that the major role of the scaffold in a drug molecule is to position those attached functional groups in a right direction and facilitate their proper interaction with biological targets. Therefore, tuning scaffolds is a proven strategy to discover drugs with improved therapeutic index.
At SyncoZymes, we have designed and synthesized over 400 novel and drug-like scaffolds. We can also design and synthesize novel scaffolds tailored to your need. Please feel free to contact us for your drug discovery needs.

 Scaffolds List    1 |2 |3 |4 |5 |6 |7 |8 |9 |10 |11 |12 |13 |14 |15 |16 |17 |18 |19 |20 |21 |22 |23 |24 |25 |    more...
ProductID
Structure
Product Name
Formula and Molecular Weight
CAS Number
SL-001A 2-(2-(tert-butoxycarbonyl)thiazol-5-yl)acetic acid C10H14N2O4S
Mol. Wt.: 258.29
723278-39-5
SL-001B tert-butyl-5-(2-aminoethyl)thiazol-2-ylcarbamate C10H17N3O2S
Mol. Wt.: 243.33
SL-001C Ethyl 2-(2-aminothiazol-5-yl)acetate C7H10N2O2S
Mol. Wt.: 186.23
859522-19-3
SL-002A 2-(methylthio)pyrazolo[1,5-a][1,3,5]triazin-4(3H)-one C6H6N4OS
Mol. Wt.: 182.2
54346-18-8
SL-002B 4-chloro-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazine C6H5ClN4S
Mol. Wt.: 200.65
54346-19-9
SL-003A 7-benzyl-4-chloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride C14H15Cl2N3
Mol. Wt.: 296.19
192869-80-0
sl-003b ethyl 2-(5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)acetate hydrochloride C11H16ClN3O2
Mol. Wt.: 257.72
1187830-52-9
SL-003C 5,6,7,8-tetrahydro-4-methoxypyrido[3,4-d]pyrimidine hydrochloride C8H12ClN3O
Mol. Wt.: 201.65
1187830-77-8
SL-003D 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one hydrochloride C7H10ClN3O
Mol. Wt.: 187.63
1171334-07-8
SL-003E 2-(7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)ethanamine C8H12ClN3
Mol. Wt.: 185.65
SL-003F 5,6,7,8-tetrahydro-4-methylpyrido[3,4-d]pyrimidine hydrochloride C8H12ClN3
Mol. Wt.: 185.65
1187830-72-3
SL-004A 6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one C14H15N3O
Mol. Wt.: 241.29
109229-22-3

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Total Records:1140
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